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KMID : 0869120010030010053
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기초간호자연과학회지
2001 Volume.3 No. 1 p.53 ~ p.61
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Temporal changes of the activity of catalase, superoxide dismutase, and glutathione peroxidase in BALB/c mice skin after a single dose UVB irradiation
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이정희/Joung Hee Lee
박경애*/이희주/박명숙/전상은/박경찬†/최스미/Kyoung Ae Park*/Hee Joo Lee/Myoung Sook Park/Sang Eun Jeon/Kyoung Chan Park†/S Mi Choi
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Abstract
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Skin is constantly exposed to air, solar radiation, ozone and other air pollutants formulating free radicals. The reactive oxygen species(ROS), formed under these conditions, are associated with skin cancers, cutaneous photoaging, and cutaneous
inflammatory disorders. In this study, we sought to establish an animal model for UVB-induced skin alteration using BALB/c mice. The level of UVB irradiation used in this model was within physiological dose. BALB/c mice were exposed to a single
dose of
UVB (200mJ/㎠) and were sacrificed at 3, 6, 24, and 48 hours following the irradiation. The effect of a single exposure to UVB irradiation on skin catalase(CAT), superoxide dismutase(SOD), and glutathione peroxidase(GPx) activities were examined.
Significant decrease in the activity of all enzymes were observed at 6 hours after irradiation(p<.05). The activity of CAT decreased more sharply than those of SOD and GPx, and then remained depressed until 48 hours after UVB irradiation, whereas
the
activity of GPx recovered to basal level at 48 h after UVB irradiation. Our results indicate that BALB/c mouse cuould be an adequate animal model of UVB irradiation experiment. These results will also provide fundamental knowledge for the
effective
nursing strategies in reducing UV-indeced skin disorders.
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KEYWORD
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